Hypothalamic sensing of fatty acids
Top Cited Papers
- 26 April 2005
- journal article
- review article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (5) , 579-584
- https://doi.org/10.1038/nn1456
Abstract
Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.Keywords
This publication has 77 references indexed in Scilit:
- Expression of three carnitine palmitoyltransferase-I isoforms in 10 regions of the rat brain during feeding, fasting, and diabetesBiochemical and Biophysical Research Communications, 2004
- Obesity Wars: Molecular Progress Confronts an Expanding EpidemicPublished by Elsevier ,2004
- Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in ratsNature Neuroscience, 2002
- Mechanisms of nutritional and hormonal regulation of lipogenesisEMBO Reports, 2001
- Metabolic predictors of weight gainInternational Journal of Obesity, 1999
- Identification of targets of leptin action in rat hypothalamus.Journal of Clinical Investigation, 1996
- Effect of intravenous nutrient infusions on food intake in ratsPhysiology & Behavior, 1989
- Sustained Intracerebroventricular Infusion of Brain Fuels Reduces Body Weight and Food Intake in RatsScience, 1981
- Obesity Genes: Beneficial Effects in Heterozygous MiceScience, 1979
- REGULATION OF ENERGY INTAKE AND THE BODY WEIGHT: THE GLUCOSTATIC THEORY AND THE LIPOSTATIC HYPOTHESISAnnals of the New York Academy of Sciences, 1955