Use of osteogenic protein-1 in the management of a nonunion radial fracture in a Squirrel Monkey (Saimiri boliviensis)*

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Abstract
Summary: A Squirrel Monkey (Saimiri boliviensis) presented with comminuted, proximal diaphyseal fractures of the left radius and ulna which were repaired with a type II acrylic external fixateur and intramedullary pin, respectively. The external fixateur was removed six weeks postoperatively as the antebrachium was stable despite radiographic evidence that the radial fracture had failed to completely heal. Eight months postoperatively, radiographic examination revealed a nonunion fracture of the proximal radial diaphysis. The nonunion fracture was stabilised with a miniplate and screws, and osteogenic protein-1 (OP-1) (bone morphogenetic protein-7) was inserted to augment bony union. Radiographic evidence of fracture healing was present four weeks postoperatively. Bone morphogenetic proteins, in particular OP-1, can be used as a substitute for autogenous cancellous bone if there is an insufficient quantity of cancellous bone or harvesting will result in unacceptable morbidity.Osteogenic protein-1 (OP-1 or bone morphogenetic protein 7) was used in the management of a nonunion fracture of the radius in a Squirrel Monkey (Saimiri boliviensis). Osteogenic protein-1 was used in preference to autogenous cancellous bone as the small size of the monkey would have limited the quantity of cancellous bone and predisposed to morbidity at the harvest site. This is the first report of the clinical use of OP-1 in veterinary surgery.
Funding Information
  • Stryker Biotech, Australia
  • Stryker Biotech, Australia