In vivo cytogenetic studies of 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2, 3, 5, 11b-tetrahydrooxazolo-[3, 2-d] [1, 4] benzodiazepine-6(7H)-one (MS-4101) on rat bone marrow cells.

Publisher Website
Google Scholar
Abstract
Chromosome aberrations induced by MS-4101, diazepam and nitrazepam were studied in Sprague-Dawley rats. Female rats were administered orally via stomach tube daily doses of 200, 500 and 2000 mg/kg of MS-4101, 200 and 500 mg/kg of diazepam, 40 and 200 mg/kg of nitrazepam and 20 and 50 mg/kg of cycophosphamide as the positive control for 1, 5 and 10 days. Bone marrow cells derived from rat femur at 6 or 24 h after the last drug administration were studied. No significant chromosome aberrations were seen in the treated groups with MS-4101, diazepam and nitrazepam when compared with the nontreated controls. The increase of structural aberration on gap and break was observed in the group of cyclophosphamide as the positive control. MS-4101, diazepam and nitrazepam, as similar comparative drugs, do not have the potential of induction of chromosome aberrations in rat bone marrow cells.

This publication has 1 reference indexed in Scilit: