Poly(ADP-ribose) Polymerase (PARP-1) in Homologous Recombination and as a Target for Cancer Therapy
- 30 June 2005
- journal article
- review article
- Published by Taylor & Francis in Cell Cycle
- Vol. 4 (9) , 1176-1178
- https://doi.org/10.4161/cc.4.9.2031
Abstract
Poly(ADP-ribose) polymerase (PARP-1) binds to DNA breaks to facilitate DNA repair. However, the role of PARP-1 in DNA repair appears to not be critical since PARP-1 knockout mice are viable, fertil...Keywords
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