Thrombin???hirudin complex stability; a comparison with the thrombin???antithrombin III complex

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Abstract
In the present in vivo study the stabilities of the thrombin-hirudin and thrombin-antithrombin III complexes were investigated. After incubation of the complexes with free inhibitors the thrombin-antithrombin III levels were determined by ELISA. The thrombin-hirudin complex proved to be stable in the presence of antithrombin III or heparin. However, in the presence of heparin and plasma equivalent concentrations of antithrombin III, the thrombin-hirudin comples dissociated and was displaced. In contrast, both thrombin-antithrombin III and thrombin-antithrombin-III/heparin complexes are very stable even in the presence of a large excess of hirudin.

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