Purification of immunologically functional subsets of human Ia-like antigens on a monoclonal antibody (Q5/13) immunoadsorbent.
Open Access
- 1 October 1980
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 125 (4) , 1421-1425
- https://doi.org/10.4049/jimmunol.125.4.1421
Abstract
Serologic and immunochemical asays have shown that the monoclonal antibody Q5/13 recognizes an antigenic determinant expressed on a subset of human Ia-like antigens. Testing with a panel of HLA typed B lymphoid cells has shown that this determinant is different from those defining the serologic polymorphism of HLA-DR antigens. The monoclonal antibody Q5/13 has been used to purify subsets of human Ia-like antigens, which are immunologically functional. These reagents should facilitate the characterization of structural and functional properties of human Ia-like antigens.Keywords
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