Nasal involvement in allergic asthma
- 3 November 2003
- Vol. 58 (12) , 1235-1243
- https://doi.org/10.1046/j.0105-4538.2003.00354.x
Abstract
Even since the late 19th century, a relationship has been suspected between upper airway disease and the subsequent development or aggravation of asthma symptoms. To date, it has been generally accepted that pathologic conditions of the upper airways, e.g. allergic rhinitis, chronic sinusitis and nasal polyposis, may influence the lower airways. However, the mechanisms underlying this relationship were, for a long time, poorly understood. Recently, evidence has been accumulating which indicates a systemic connection as one of the responsible mechanisms in nasobronchial crosstalk. In this review, the pathophysiologic and immunologic aspects of the interaction between upper and lower airways will be discusseKeywords
This publication has 101 references indexed in Scilit:
- Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjectsThorax, 2001
- Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthmaJournal of Allergy and Clinical Immunology, 2001
- Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airwaysJournal of Allergy and Clinical Immunology, 2001
- Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocationJournal of Allergy and Clinical Immunology, 2000
- Allergic rhinitis and asthma: How important is the link?☆☆☆★Journal of Allergy and Clinical Immunology, 1997
- Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for AtopyNew England Journal of Medicine, 1995
- Nasal challenge with allergen upregulates the local expression of vascular endothelial adhesion moleculesJournal of Allergy and Clinical Immunology, 1994
- Blood and bronchoalveolar eosinophils in allergic subjects after segmental antigen challenge: Surface phenotype, density heterogeneity, and prostanoid productionJournal of Allergy and Clinical Immunology, 1994
- Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsivenessJournal of Allergy and Clinical Immunology, 1991
- Enhancement of Exercise-Induced Asthma by Cold AirNew England Journal of Medicine, 1977