Safety Evaluation of Perfumed Shampoos: Dose/Response Relationships for Product use Testing by Presensitized Subjects
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology- Cutaneous and Ocular Toxicology
- Vol. 3 (1) , 65-72
- https://doi.org/10.3109/15569528409036273
Abstract
A perfume prepared from equal amounts of hydroxycitronellal, geraniol, and lyral was added at various levels to an unperfumed shampoo and distributed for ad libitum use to 12 test subjects with preexisting contact hypersensitivities to either hydroxycitronellal or geraniol. The initial levels of perfume were 30% to 40% (or less) than the subject's 48-hr patch-test threshold concentration for response lo either hydroxycitronellal or geraniol in petrolatum, whichever was lower. At 2-week inter vals shampoo perfume levels were increased threefold if no subjective or visible skin reactions occurred. Five percent of each perfume ingredient (15% total) was the maximum level used. Two of the 12 subjects (both presensitized to hydroxycitronellal) showed evidence of allergic responses upon shampoo use at the 5% level, but not at the 3% level, thereby demonstrating the presence of a threshold of response. The 3% level represents a factor of 30 and 120 times these two subjects’ 48-hr closed patch threshold to hydroxycitronellal.This publication has 3 references indexed in Scilit:
- Perfume dermatitis. a study of 20 patientsArchives of Dermatology, 1977
- Perfume DermatitisArchives of Dermatology, 1977
- Contact Dermatitis Due to Oil of CitronellaJournal of Investigative Dermatology, 1947