Linkage mapping of systemic lupus erythematosus (SLE) in Finnish families multiply affected by SLE
Open Access
- 1 January 2004
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 41 (1) , 2e-5
- https://doi.org/10.1136/jmg.2003.009977
Abstract
Stratification of pedigrees based on clinical manifestations has been used in recent studies that involved genomewide scans.10– 16 The aim was to achieve genetically and clinically homogeneous sets of families and to increase the power to detect susceptibility genes for different subphenotypes of SLE. Altogether, 17 regions have been linked significantly to SLE with model based and non-parametric approaches; 11 of these in stratified studies. In addition, several other regions with suggestive linkage have been identified, but only some of those loci have been implicated in more than one study.6, 18 The data suggest that multiple genes are involved in conferring susceptibility to SLE.Keywords
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