Amino Acids and Peptides; 75. Synthesis of Di- and Trihydroxyamino Acids - Construction of Lipophilic Tripalmitoyldihydroxy-α-amino Acids
- 1 January 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1991 (01) , 49-55
- https://doi.org/10.1055/s-1991-26378
Abstract
Suitable protected derivatives of trihydroxynorleucines-[(2S,4S,5S)- and (2R,4S,5S)-2-amino-4,5,6-trihydroxyhexanoic acid,] of all isomeric dihydroxynorvalines [2-amino-4,5-dihydroxypentanoic acids), of all isomeric 2-amino-6,7-dihydroxyheptanoic acids and of (2S)-2-amino-6-hydroxymethyl-7-hydroxyheptanoic acid are synthesized via the corresponding α,β-didehydro compounds, which are hydrogenated with the optically active homogeneous catalyst [Rh(COD)(DIPAMP)]+ BF- 4.Keywords
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