Another approach to in vivo estimation of genetic damage in humans.
- 1 January 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (1) , 462-463
- https://doi.org/10.1073/pnas.76.1.462
Abstract
Direct measurements of the genetic hazards to man have been determined previously by the appearance of elevated in vivo levels of chromosome aberrations. Here we report that interindividual variations in N-acetoxy-2-acetyl-aminofluorene-induced unscheduled DNA synthesis values parallel the actual in vivo levels of chromosome damage and, therefore, may be a rapid useful supplement in genetic risk assessment for humans.This publication has 15 references indexed in Scilit:
- Interindividual variation in the responses of cultured human lymphocytes to exposure from DNA damaging chemical agentsMutation Research/Environmental Mutagenesis and Related Subjects, 1978
- CHROMOSOME ABERRATIONS IN CHRONIC ALCOHOLICSThe Lancet, 1978
- Differences in removal of acetylaminofluorene and pyrimidine dimers from the DNA of cultured mammalian cells.Proceedings of the National Academy of Sciences, 1977
- DETECTION OF CHEMICAL CARCINOGENS BY UNSCHEDULED DNA-SYNTHESIS IN RAT-LIVER PRIMARY-CELL CULTURES1977
- CHROMOSOME ABERRATIONS AND METRONIDAZOLEThe Lancet, 1976
- High blood pressure related to carcinogen-induced unscheduled DNA synthesis, DNA carcinogen binding, and chromosomal aberrations in human lymphocytes.Proceedings of the National Academy of Sciences, 1976
- Lymphocyte chromosome studies in humans exposed to chemical mutagensMutation Research/Genetic Toxicology, 1976
- Evaluation of short-term tests for carcinogenicityToxicology and Applied Pharmacology, 1974
- Preferential DNA Repair in Human CellsNature, 1974
- The repair of X-ray-induced chromosome aberrations in stimulated and unstimulated human lymphocytesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972