Bactericidal response of channel catfish (Ictalurus punctatus) by the classical and alternative complement pathways against bacterial pathogens

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Abstract
The alternative and classical complement pathways of channel catfish (Ictalurus punctatus), most importantly the classical complement pathway which requires antibody, demonstrated bactericidal activity against two Gram-negative bacterial fish pathogens, Flexibacter columnaris and Vibrio anguillarum. This shows the importance of antibody-mediated bactericidal immunity in fish by the classical complement pathway in providing protection following immunization or natural infections.
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