Inhibitors of endothelin
- 1 January 1997
- journal article
- review article
- Published by Wiley in Medicinal Research Reviews
- Vol. 17 (1) , 17-67
- https://doi.org/10.1002/(sici)1098-1128(199701)17:1<17::aid-med2>3.0.co;2-w
Abstract
With the advent of the first generation of both selective and nonselective endothelin antagonists being a relatively recent event, the manifold therapeutic potentials of these compounds are only now being explored clinically. Undoubtedly, numerous clinical utilities for these compounds will soon be realized.Keywords
This publication has 115 references indexed in Scilit:
- Kinetic analyses demonstrate that the equilibrium assumption does not apply to [125I]endothelin-1 binding dataLife Sciences, 1992
- Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptorLife Sciences, 1992
- Cloning and characterization of cDNA encoding human a-type endothelin receptorBiochemical and Biophysical Research Communications, 1991
- Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptorBiochemical and Biophysical Research Communications, 1991
- Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypesBiochemical and Biophysical Research Communications, 1991
- Receptor kinetics differ for endothelin-1 and endothelin-2 binding to Swiss 3T3 fibroblastsBiochemical and Biophysical Research Communications, 1990
- Pituitary site of action of endothelin: Selective inhibition of prolactin release in vitroBiochemical and Biophysical Research Communications, 1990
- Endothelin stimulates a sustained 1,2-diacylglycerol increase and protein kinase C activation in bovine aortic smooth muscle cellsBiochemical and Biophysical Research Communications, 1989
- Two distinct types of endothelin receptors are present on chick cardiac membranesBiochemical and Biophysical Research Communications, 1989
- Specific receptors for endothelin on membranes from human placenta. Characterization and use in a binding assayLife Sciences, 1989