Inhibition of Rat Cholinesterases by Tritolyl Phosphates.

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Abstract
Triorthotolyl phosphate inhibits the cholinesterases of erythrocytes, brain, and plasma in the rat, causing typical signs of cholinesterase inhibition when activity has fallen below 20% of normal in the brain or erythrocytes. Inhibition of erythrocyte cholinesterase is more severe than inhibition of plasma cholinesterase, although the activity did not decrease as rapidly. No paralysis resulted from either single or multiple administration. Trimeta- and triparatolyl phosphates caused no inhibition of brain or erythrocyte cholinesterase on single or multiple administration. Trimetatolyl phosphate caused inhibition of plasma cholinesterase. These studies help to clarify the pharmacologic action of tritolyl phosphates in different species.