Comparative studies on the serum levels of .ALPHA.-1-antitrypsin and .ALPHA.-macroglobulin in several mammals.

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Abstract
The sera of human, cattle, horse, sheep, goat, pig, dog, rabbit, guinea pig, rat, hamster and mouse were assayed for total trypsin-inhibiting capacity, and for concentrations of .alpha.-1-antitrypsin and .alpha.-macroglobulin. The rodents examined showed striking species differences: the .alpha.-1-antitrypsin levels of mouse, rat, and guinea pig were more than twice the human level, while the .alpha.-macroglobulin levels of hamster and guinea pig were 340 and 40%, respectively, of the human level. Little variation was found among the large domestic animals, their levels of the 2 inhibitors being similar to those of the human.