Lack of Protective Immunity Against Reinfection with Hepatitis C Virus
- 2 October 1992
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 258 (5079) , 135-140
- https://doi.org/10.1126/science.1279801
Abstract
Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpanzees sequentially inoculated over a period of 3 years with different HCV strains of proven infectivity. Each rechallenge of a convalescent chimpanzee with the same or a different HCV strain resulted in the reappearance of viremia, which was due to infection with the subsequent challenge virus. The evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.Keywords
This publication has 53 references indexed in Scilit:
- The Natural History of Infection with Hepatitis C Virus (HCV) in Chimpanzees: Comparison of Serologic Responses Measured with First- and Second- Generation Assays and Relationship to HCV ViremiaThe Journal of Infectious Diseases, 1992
- Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral diseaseHepatology, 1991
- Hypervariable regions in the putative glycoprotein of hepatitis C virusBiochemical and Biophysical Research Communications, 1991
- The Putative Nucleocapsid and Envelope Protein Genes of Hepatitis C Virus Determined by Comparison of the Nucleotide Sequences of Two Isolates Derived from an Experimentally Infected Chimpanzee and Healthy Human CarriersJournal of General Virology, 1990
- Frequent Detection of Hepatitis C Virus US Strain in Japanese HemophiliacsJapanese Journal of Cancer Research, 1990
- The significance of infections with two types of viral hepatitis demonstrated by histologic features in chimpanzeesJournal of Hepatology, 1990
- Detection of Antibody to Hepatitis C Virus in Prospectively Followed Transfusion Recipients with Acute and Chronic Non-A, Non-B HepatitisNew England Journal of Medicine, 1989
- Long-Term Sequelae of Non-A, Non-B Hepatitis in Experimentally Infected ChimpanzeesHepatology, 1984
- Additional evidence for more than one agent of human non‐A, non‐B hepatitis. Transmission and passage studies in chimpanzeesTransfusion, 1984
- Multiple Hepatitis Viruses in Multiple Attacks of Acute Viral HepatitisNew England Journal of Medicine, 1977