Studies of 7.BETA.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. II. Synthesis and structure-activity relationships in the aminopyrimidine series.

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Abstract
The synthesis and the antibacterial activity of 7.beta.-[2-(aminopyrimidinyl)-2-oxyiminoacetamido]cephalosporins with various substituents at the 3-position in the cephem nucleus are described. The 7.beta.-[2-(4-aminopyrimidin-2-yl)-2-methoxyiminoacetamido]cephalosporin derivative showed significantly higher activity than the corresponding 2-aminopyrimidin-4-yl derivative against gram-negative bacteria. It was also higher in potency against Escherichia coli and Serratia marcescens than the aminopyridyl compound.