The role of macrophages on the expression of sex difference in the susceptibility toBrugia pahangiinfection in C57BL/6 mice

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Abstract
The role of macrophages or eosinophils on the expression of sex difference in the susceptibility to a primaryBrugia pahangiinfection in C57BL/6 mice was investigated by using a macrophage blockade technique (carbon treatment) or a histamine type 1 (H1) receptor antagonist (promethazine). Carbon treatment remarkably inhibited macrophage exudation, reduced the resistance of female mice, and completely abolished sex difference in the susceptibility toB. pahangiinfection. Although promethazine treatment inhibited eosinophil exudation, it caused only a little increase (not significant) in the recovery rate of worms. These results suggest that macrophages have more important role(s) than do eosinophils on the expression of sex difference in the susceptibility to a primaryB. pahangiinfection in C57BL/6 mice.