Condyloma acuminatum in Rochester, Minn, 1950-1978. II. Anaplasias and unfavorable outcomes

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Abstract
Patients (746) with condyloma acuminatum were diagnosed between 1950-1978. Anaplasia was present in 6, and subsequently developed in 36 patients during follow-up examinations in 42 patients (1 male and 41 females). One had invasive squamous cell carcinoma (vulva), 6 had severe dysplasias, 21 had moderate to mild dysplasias and 14 had carcinomas in situ (CIS), of which 11 were cervical. In the female patients, 37 of the anaplasias were cervical and the other 4 were vulval or vaginal. The 11 cervical CIS amounted to 3.8 times the expected number of 2.9, based on an earlier study of cervical cancer incidence in the community. The risk of cervical CIS developing among patients with condyloma is significantly higher than expected. Neither laryngeal papilloma nor other unfavorable outcomes substantially affected the conceptus of 51 pregnancies in women with concurrent condyloma. There appears to be an association between condyloma and genital malignant neoplasms, and a relationship of condyloma with sexually transmitted disease and warts.