Relationship between weight gain and lymph flow in dog lungs

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Abstract
Lung weight is a useful indicator of increases in lung extravascular volume. In addition, the lung lymph flow rate (.ovrhdot.QL) is an important factor in lung fluid balance. The weight and .ovrhdot.QL responses to evaluations in capillary pressure (Pc) were studied in intact dog lung lower left lobes. Lobe weight was measured continuously. .ovrhdot.QL from small lymph vessels from the same lobes was also measured. The base-line .ovrhdot.QL was 1.7 .+-. 1.5 .mu.l/min, and the weight was constant. After Pc was increased by 8-20 cmH2O, both weight and .ovrhdot.QL increased transiently. In most lungs the weight reached a new steady state. When Pc was increased further, weight increased continuously; however, .ovrhdot.QL reached a plateau. The continuous weight gain was due to edema. Apparently, weight and .ovrhdot.QL respond similarly in non-edematous lungs; however, the weight and .ovrhdot.QL responses in edematous lungs may be different.

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