TIME COURSE OF URINARY EXCRETION OF INORGANIC PHOSPHATE BY RATS AFTER PARATHYROIDECTOMY AND AFTER INJECTION OF PARATHYROID EXTRACT1

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Abstract
Spontaneously voided urine was collected at intervals of 5 to 15 minutes from unanesthetized male rats in metabolic restraining cages during continuous intravenous infusion of physiological salt solution and anatyzed for inorganic phosphate (Pi). The rate of excretion of Pi fell within 25 to 52 minutes after parathyroidectomy and continued to decline during the next 3 to 5 hours. At the end of this interval the intravenous injection of parathyroid extract resulted, within 8 minutes, in a rise in urinary Pi. The rate continued to increase to a maximum, 18 to 48 minutes after the injection, which was within the range of the pro-operative values. The rate fell gradually toward the pre-injection level during the next one to one and a half hours. The work led to the following conclusions: the life of parathyroid hormone in the circulation is short; in the normal intact rat there is a continuous secretion of the hormone; the hormone acts directly on the renal tubule to influence the excretion of Pi