CONTROLLED ERGOMETRIC STUDIES OF EFFECT OF HEPARIN ON INTERMITTENT CLAUDICATION

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Abstract
Clinical experience has demonstrated the need for an accurate method for the determination of claudication time.* The subjective report of the patient with intermittent claudication is frequently extremely variable and has proved unsatisfactory for the evaluation of therapy in occlusive vascular disease. The time of onset of claudication pain may be influenced by the rate of walking,1 the gradient of the incline on which the walking is done, and psychological factors. Patients frequently report variations in claudication time apparently related to environmental temperature or humidity. Interest in this subject was renewed following the report of Graham and co-workers,2 later confirmed by Engelberg,3 suggesting that intermittent heparin administration resulted in relief of angina pectoris in patients with coronary arteriosclerosis. Recognizing the difficulty in evaluating the effect of any treatment for angina as well as the basic similarity of angina and claudication,4 we have endeavored to determine objectively