Lipid absorption by silicone heart valve poppets—in‐vivo and in‐vitro results

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Abstract
Silicone rubber poppets, apparently without exception, will absorb lipid from the blood stream. In most cases, absorption is quite low and confined to simple lipids like cholesterol and cholesterol esters. A small percentage, however, absorb an unknown material in quantities sufficient to render them variant. This material appears to be an oxidation product of polyunsaturated fatty acids formed after their absorption into the poppet by the action of molecular oxygen. In vitro experiments supporting the in vivo findings are described.

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