Muscle biopsy in AIDS and ARC: Analysis of 50 patients
- 1 June 1990
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 13 (6) , 541-544
- https://doi.org/10.1002/mus.880130611
Abstract
We report a large spectrum of histological muscle abnormalities in 50 homosexual men with AIDS and ARC. We encountered moth‐eaten fibers in 76%, angulated fibers in 76%, type groupings in 62%, type 2 fiber atrophy in 58%, mononuclear endomysial and/or perivascular in filtrates in 36%, necrosis and phagocytosis in 30%, and target fibers in 6%. Two patients showed vasculitis and two others showed perifascicular atrophy. On the whole, 96% of the biopsies showed substantial abnormalities. Muscle involvement in AIDS seems more common than previously suspected.Keywords
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