Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposme to 12-O-tetradecanoylphorbol-13-acetat

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Abstract
Tumor-promoting phorbol esters are potent inflammatory agents. Inflammation has long been associated with carcinogenesis, particularly the promotion. SENCAR mice have been bred for their sensitivity to the promotion of skin tumors by phorbol esters whereas C57BLl6 mice have been shown to be resistant. When 12- O -tetradecawylphorbol-13 acetate (TPA) was applied to the skin of SENCAR and CS7BL/6 mice, SENCAR mice had a much more intense inflammatory response than the C57BL/6 animals. There was more edema formation at the site of application and vascular permeability was also greatly enhanced in the SENCAR strain. When samples of skin were examined microscopically, a fulminant, acute inflammatory cellular infiltrate was observed in SENCAR mice. Very few inflammatory cells migrated into the skin of C57BL/6 mice. At higher doses and multiple exposum to TPA there was a hyperplastic response of the keratinocytes in C57BL/6 mice, but it was less intense than in SENCAR mice. These data demonstrate that enhanced inflammatory resporms in TPA in the skin correlate with the sensitivity to the promotion of skin tumors by TPA.