Tandem Conjugate Reduction−Aldol Cyclization Using Stryker's Reagent
- 16 May 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (12) , 1901-1903
- https://doi.org/10.1021/ol015944n
Abstract
Conjugate reduction by Stryker's reagent to form copper enolates, followed by intramolecular aldol cyclization, successfully generated five- and six-membered carbocycles in one pot efficiently. This tandem reaction is generally diastereoselective and provides good yields of the β-hydroxyketones without any dehydration at low temperatures.Keywords
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