ORAL-CONTRACEPTIVES AND POST-MOLAR TROPHOBLASTIC DISEASE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 58  (4) , 474-477
Abstract
Patients (100) managed for molar pregnancy, were selected at random to determine if the contraceptive method following molar evacuation influenced the incidence of post-molar trophoblastic disease. Following molar evacuation, 58 (58%) patients used oral contraceptives and 42 (42%) patients used barrier methods (foam, condom and/or diaphragm). Postmolar trophoblastic disease developed in 11 (18.9%) patients using oral contraceptives and in 6 (14.3%) patients using barrier methods (P > 0.10). The mean human chorionic gonadotropin (hCG) regression time after molar evacuation was 7.0 wk in patients using oral contraceptives and 7.2 wk in patients using barrier methods. The 2 groups of patients were comparable in age, gravidity, molar histology, pretreatment hCG titers and exposure to prophylactic chemotherapy. Oral contraceptives do not appear to increase the risk of postmolar trophoblastic tumors and therefore may be safely prescribed after molar evacuation during the entire interval of hCG monitoring.

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