Changes in Electroencephalogram of the Rat Following Olfactory Bulbectomy

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Abstract
The changes in electrical activities following olfactory bulbectomy were investigated in rats with chronically implanted electrodes, in comparison with those induced by septal lesions. EEG of the amygdala changed to low voltage fast waves immediatley after bilateral olfactory bulbectomy, while EEG of the neocortex gradually showed an arousal pattern consisting of low voltage fast waves. Hippocampal theta waves were markedly synchronized for about a week after bulbectomy with accompanying hyperemotionality. No change was observed in EEG of the septum, hypothalamus or the midbrain reticular formation. Following unilateral olfactory bulbectomy, no behavioral changes occurred, but EEG of the ipsilateral amygdala showed low voltage fast activity without causing any EEG changes in other brain structures. Bilateral septal lesions immediately caused hyperreactivity in rats which gradually disappeared during the course of a week or 2 after surgery. The hippocampal theta activity completely disappeared and EEG turned to low voltage fast waves immediately after septal lesions, but no significant EEG change was observed in the amygdala or the neocortex. This change in hippocampal EEG continued for a long time even after hyperreactivity disappeared.

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