Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells
- 23 September 1994
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 265 (5180) , 1869-1871
- https://doi.org/10.1126/science.7916481
Abstract
Indirect evidence implicates γδ T cells in the cross-regulation of CD4 αβ T cell responses. Adoptive transfer of small numbers of γδ T cells from ovalbumin (OVA)-tolerant mice selectively suppressed T H 2 -dependent immunoglobulin E(IgE) antibody production without affecting parallel IgG responses. Challenge of these γδ T cells in vitro with specific antigen resulted in production of high levels of interferon γ. The effects of the γδ T cells may be mediated by direct inhibition of OVA-specific CD4 + T H 2 cell proliferation or selection for specific CD4 T H 2 cells.Keywords
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