ORAL ULCERATION AND LYMPHOCYTE REACTIONS IN RHEUMATOID-ARTHRITIS PATIENTS ON GOLD THERAPY

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Abstract
In an attempt to determine if oral ulceration in rheumatoid arthritis patients on gold therapy had an immunological basis, peripheral blood lymphocytes have been examined for mitotic activity, migration inhibition factor and cytotoxic lymphokines. Healthy and rheumatoid controls were compared with rheumatoid patients under treatment with gold. The latter group was further subdivided according to the development of oral ulceration whilst undergoing chrysotherapy, since abnormalities in lymphocyte behaviour have been found in subjects with aphthous ulceration. The only difference found between rheumatoid patients with gold-induced oral ulceration and those on gold without oral lesions was slight depression of specific mitogenic reactivity. With the phytohacmagglutinin stimulation index, the rheumatoid group as a whole differed from controls in having a significantly higher rate of turnover.

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