Novel findings about 24,25-dihydroxyvitamin D: an active metabolite?
- 1 July 1999
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Nephrology and Hypertension
- Vol. 8 (4) , 435-441
- https://doi.org/10.1097/00041552-199907000-00007
Abstract
The physiological role of 24,25-dihydroxyvitamin D remains controversial. Recent results suggest that 24,25-dihydroxyvitamin D is essential for fracture healing, and binding sites for 24,25-dihydroxyvitamin D have been identified in fracture callus tissue. Mice deficient in the 25-hydroxyvitamin D-24-hydroxylase enzyme provide novel genetic tools in which to study the role of 24,25-dihydroxyvitamin D in bone development and fracture repair.Keywords
This publication has 24 references indexed in Scilit:
- The Synergistic Effects of Vitamin D Metabolites and Transforming Growth Factor- on Costochondral Chondrocytes Are Mediated by Increases in Protein Kinase C Activity Involving Two Separate PathwaysEndocrinology, 1998
- 24,25-(OH)2D3 Regulation of Matrix Vesicle Protein Kinase C Occurs Both During Biosynthesis and in the Extracellular MatrixCalcified Tissue International, 1997
- Interleukin-1α and β in Growth Plate Cartilage Are Regulated by Vitamin D Metabolites In VivoJournal of Bone and Mineral Research, 1997
- 24R,25-Dihydroxyvitamin D3: An Essential Vitamin D3 Metabolite for Both Normal Bone Integrity and Healing of Tibial Fracture in ChicksEndocrinology, 1997
- Three-Fold Induction of Renal 25-Hydroxyvitamin D3-24-Hydroxylase Activity and Increased Serum 24,25-Dihydroxyvitamin D3 Levels Are Correlated with the Healing Process After Chick Tibial FractureJournal of Bone and Mineral Research, 1997
- Human 25-Hydroxyvitamin D3-24-Hydroxylase, a Multicatalytic EnzymeBiochemistry, 1996
- Treatment of resting zone chondrocytes with 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] induces differentiation into a 1,25-(OH)2D3-responsive phenotype characteristic of growth zone chondrocytesEndocrinology, 1995
- Further Oxidation of Hydroxycalcidiol by Calcidiol 24‐HydroxylaseEuropean Journal of Biochemistry, 1994
- Direct effects of transforming growth factor-beta on chondrocytes are modulated by vitamin D metabolites in a cell maturation-specific mannerEndocrinology, 1993
- Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidationBiochemical Journal, 1989