Cis (IS,3R)-1-(9-Adenyl)-3-Hydroxycyclopentane Inhibits the Respiratory Burst from Polymorphonuclear Leukocytes and HasIn VivoEfficacy in an Acute and Chronic Model of Inflammation
- 1 May 1996
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 15 (5) , 967-979
- https://doi.org/10.1080/07328319608002028
Abstract
The adenine-containing carbocyclic nucleosides 1 and 2 were synthesized in optically active form and have been shown to effectively inhibit interferon-gamma priming of Lewis (LEW/N) rat air pouch-derived PMNs. Compound 2 was also shown to have in vivo activity in a LEW/N rat antigen-induced arthritis model which assesses acute and chronic inflammation.Keywords
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