The Nature of Pressor Substances in Pheochromocytomas

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Abstract
The actions of aqueous extracts of two pheochromocytomas are compared before and after the administration of the adrenergic blocking agent, Dibenamine. One tumor contained predominantly a substance which, like norepinephrine, had pressor actions after Dibenamine. The other tumor contained chiefly an epinephrine-like substance. The significance of the presence of norepinephrine in pheochromocytomas and its role in epinephrine metabolism are discussed.