Frequency and Organ Distribution of Lung Tumor Metastases in CF-1 Mice

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Abstract
Eighty-seven metastasizing lung tumors were found in CF-1 mice under various experimental conditions. The total number of mice of both sexes was 4608, of which 2439 had lung tumors. The incidence of metastasizing tumors in control mice ranged from 0 to 4% in relation to the total number of mice with lung tumors. The incidence in the largest group of untreated mice was 1.8% (5 with tumor metastases of 281 lung tumor-bearing mice). Treatment with urethan, methylcholanthrene, and diethylnitrosamine, which considerably increased the overall incidence of lung tumors, did not significantly alter the rate of metastasis which varied in different groups from 0 to 14%. The preferential sites of lung tumor metastases were mediastinal lymph nodes (57 mice), chest wall (31), heart (29), kidney (24), liver (12), and paraosteal tissues. Thirty-eight mice had metastases in 1 organ only (most frequently the mediastinal lymph nodes). In 24, 10, and 15 mice, 2, 3, and 4 or more sites, respectively, were affected with metastases. Primary lung tumors, and particularly their metastases, frequently had an admixture of sarcoma-like structures.

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