Chromosomal Abnormalities in Congenital Rubella

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Abstract
WHEN the rubella virus infects a human fetus early in its development congenital malformations may ensue. The mechanism of this teratogenic effect is not known. It has been demonstrated1 that when the rubella virus is added to tissue cultures of human embryonic origin chromosomal breaks frequently occur. The teratogenic effect of this virus may thus be explained by its action upon genetic material at a critical stage in embryonic development. Previous cytogenetic studies of children with congenital rubella seemed to contradict this hypothesis. Mellman et al.2 analyzed the chromosomes in cultured leukocytes of 6 newborn infants with congenital rubella and . . .

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