Network motif analysis of a multi-mode genetic-interaction network
Open Access
- 2 August 2007
- journal article
- Published by Springer Nature in Genome Biology
- Vol. 8 (8) , R160
- https://doi.org/10.1186/gb-2007-8-8-r160
Abstract
Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such methods and implemented them in open-source software. Motifs extracted from multi-mode genetic-interaction networks form functional subnetworks, highlight genes dominating these subnetworks, and reveal genetic reflections of the underlying biochemical system.Keywords
This publication has 37 references indexed in Scilit:
- Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction mapNature, 2007
- Regulation of Mating and Filamentation Genes by Two Distinct Ste12 Complexes in Saccharomyces cerevisiaeMolecular and Cellular Biology, 2006
- Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray ProfileCell, 2005
- Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiaeinteraction networkJournal of Biology, 2005
- Derivation of genetic interaction networks from quantitative phenotype dataGenome Biology, 2005
- Global Mapping of the Yeast Genetic Interaction NetworkScience, 2004
- Transcriptional Regulatory Networks in Saccharomyces cerevisiaeScience, 2002
- Network Motifs: Simple Building Blocks of Complex NetworksScience, 2002
- Network motifs in the transcriptional regulation network of Escherichia coliNature Genetics, 2002
- Differential regulation of transcription: Repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteinsProceedings of the National Academy of Sciences, 1998