Pathogenicity of a Viral Strain (RPL12) Causing Avian Visceral Lymphomatosis and Related Neoplasms. II. Host-Virus Interrelations Affecting Response

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Abstract
A study was made of the disease-response in chickens experimentally exposed by different methods to various sources of virus or viruses causing visceral lymphomatosis and related neoplasms. All sources of virus that caused visceral lymphomatosis also caused erythroblastosis. These included tumors from 7 different naturally infected chickens from various sources, embryos from 28 different hens, as well as oral washings and fecal collections from 9 different hens. Filtrates of tumors and other materials from 5 of the 7 propagated lymphoid-tumor strains caused osteopetrosis in addition to erythroblastosis and visceral lymphomatosis. Hemangiomas and fibrosarcomas or myxosarcomas were also observed in chickens of certain strains and passages, but there were few myelocytomas or incidences of neurolymphomatosis, ocular lymphomatosis, and granuloblastosis. A variation in the dose of virus had a marked effect on the type of response. High doses primarily caused erythroblastosis, which occurred in less than 4 months, and low doses resulted in a response that was primarily visceral lymphomatosis, with death occurring after 4 months. Variations in the type and quantity of response following exposure by different methods (including contact) and to different sources of virus were obtained. These variations can be most logically explained on the basis of a variable level of effective virus.

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