Effect of Antrum Transplantation on Gastric Secretion in Experimental Animals.

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Abstract
Quantitative collections of gastric juice from Pavlov and Heidenhain pouch dogs, and from animals with totally isolated stomach prepns. were made for control periods lasting several weeks. The antrum of the stomach was then separated from the fundus, using great care not to interfere with its blood supply, and subsequently transplanted as a diverticulum into the duodenum and into the colon. Whenever the antrum was excluded from the gastro-intestinal tract so that it did not come in contact with food, a profound reduction in gastric secretion resulted. When the antrum was transplanted into the duodenum, a very profound augmentation in gastric secretion resulted, and this was even more marked when the antrum was transplanted into the colon. These findings support the view that the antrum mucosa is a specific internal secreting organ distinct in function from the mucous membrane of the remainder of the stomach or duodenum.

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