The Cell Surface Antigens of Bladder Washing Specimens in Patients with Bladder Tumors, A New Approach

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Abstract
The blood group antigens A, B and O(H) are present on the cell surface of many tissues, including the urothelium. Loss of these antigens from the surface of tumor cells correlates with subsequent development of invasion. Since the specific red cell adherence test demonstrates the presence or absence of these antigens the test may have important prognostic and screening value. Bladder washing specimens from patients with bladder tumors and normal controls were examined for this phenomenon. Results in patients with bladder tumors were compared to original biopsy specimens for the presence or absence of cell surface antigens. The technique presents a simple, reliable test that may be significant in screening as well as follow-up of patients with bladder cancer.