Histamine Synthesis by Bone Marrow-derived Macrophages

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Abstract
Histamine may be involved in the regulation of hematopoiesis. However, it remained obscure what kind of cells are responsible for its synthesis in bone marrow (BM). In this study, a pure population of macrophages were raised from BM of W/Wv mice, which are genetically deficient in mast cells. The addition of Escherichia coli lipopolysaccharide (LPS) or murine recombinant granulocyte/macrophage colony-stimulating factor (mrGM-CSF) alone had essentially no effect on histamine synthesis. However, the latter rendered the cells responsive to LPS, leading to a marked increase in HDC-dependent histamine synthesis.

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