Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals

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Abstract
The authors examined the association of total plasma homocysteine (Hcy) levels with measures of atrophy and white matter disease on MRI scans in 36 healthy elderly individuals. Hcy had a significant positive relationship with lateral ventricle–brain ratios in the anterior (r = 0.49) and middle (r = 0.43) ventricular regions as measures of central atrophy, but not with cortical atrophy or white matter hyperintensities. In a logistic regression analysis, elevated Hcy was a significant determinant of increased anterior ventricle–brain ratio (≥0.34) after controlling for age, folate, B12, creatinine, and white matter disease (OR = 2.3; CI, 1.03–5.09).