Effects of Pretreatment with Anti-Inflammatory Drugs on Ozone-Induced Lung Damage in Rats

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Abstract
The effects of pretreatment with acetylsalicylic acid (aspirin), hydrocortisone, indomethacin and heparin administered i.p. against the pulmonary edema produced by O3-exposure (4 ppm for 4 h) were studied in rats. These anti-inflammatory drugs altered the injurious effect of O3 on lung differently. Aspirin at the high dose (125 mg/kg) accentuated O3-induced lung injury, and had no effect at the low dose (10 mg/kg); hydrocortisone (50 mg/kg) failed to have any effect; indomethacin at a high dose (20 mg/kg) offered a significant degree of protection, but had no effect at the low dose (2.5 mg/kg); and heparin (1000 units/kg) also offered a significant degree of protection against the lung damage normally induced by O3-exposure. Several mechanisms for the favorable and unfavorable interactions of anti-inflammatory drugs with O3-exposure are discussed.

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