Use of Radioactive Iodine for Thyroid Cancer
Top Cited Papers
Open Access
- 17 August 2011
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 306 (7) , 721-728
- https://doi.org/10.1001/jama.2011.1139
Abstract
More than 40 000 individuals in the United States receive a thyroid cancer diagnosis each year, and the overwhelming majority of cases are well-differentiated thyroid cancer.1 Standard treatment for well-differentiated thyroid cancer is thyroidectomy. To ensure full eradication of remnant thyroid tissue and to treat residual disease, in patients with visible, inoperable, iodine-avid metastases, radioactive iodine is often administered after total thyroidectomy. Previous cohort studies have shown improved survival and reduced tumor recurrence when iodine-avid, advanced-stage, well-differentiated thyroid cancer is treated with radioactive iodine.2-4 There is little controversy concerning the value of radioactive iodine for these patients. In contrast, for very low-risk disease, in which prognosis is typically excellent, treatment with radioactive iodine is of uncertain benefit.5-8Keywords
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