The peroxidase activity and cellular content of granule proteins in PMN during pregnancy

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Abstract
The cellular content of myeloperoxidase (MPO), chymotrypsin-like cationic protein (CCP) and lactoferrin (LF) of isolated polymorphonuclear leukocytes (PMN) from pregnant women were analyzed by immuno-chemical methods. The cellular levels of MPO and CCP were unaltered during pregnancy while the cellular levels of LF were increased during pregnancy and post partum (P < 0.01). Peroxidase activity within isolated PMN was analyzed by 2 methods, a Guaiacol method and a chemiluminescence method. The activity was found to be reduced during pregnancy. The reduction was explained by the reduction in eosinophil peroxidase which in turn was a consequence of a reduced number of circulating eosinophils during pregnancy.