Platelet function and clotting parameters of vibration-exposed foundry workers.

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Abstract
Platelet aggregation and blood clotting parameters were studied in 22 workers (84%) using pneumatic riveting and grinding hand tools and in 20 workers (90%) not exposed to vibration but comparable with respect to age, anthropometric data, smoking and drinking habits and atherogenic risk factors. The weighted acceleration levels of the vibrating tools were reported. According to Taylor''s grading system for vibration-induced white fingers, 15 exposed workers (57%) were in stage 0T, 9 (34%) in stage 0N and 1 (4%) in stage 1. Between the reference and the vibration-exposed groups no differences in the platelet aggregation indices in vitro (ADP, epinephrine, threshold ADP concentration) and in vivo (platelet factor 4, .beta.-thromboglobulin) were found. The clotting parameters (prothrombin index, activated partial thromboplastin time, fibrinogen, antithrombin III) and Ig G, A and M were normal in the 2 groups. The measurement of skin temperature of the 3rd right finger before and after the cold provocation test showed that the vibration exposed workers experienced a stronger vasoconstriction of the digital vessels than the referents. In the early stages of vasopastic disorders, segmental vibration can induce peripheral vascular hyperreactivity without charges in the platelet function and clotting parameters.

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