Suggested Sequence of Testing for Acne Patients Receiving Long-Term Tetracycline Therapy

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To the Editor.— After completion of my study on the safety of long-term tetracycline therapy for acne (Arch Dermatol 112:1603-1605, 1976), it seemed to me that physicians would appreciate some suggestions concerning blood testing for acne patients who are receiving long-term tetracycline therapy. The following sequence for testing is suggested, but this is not meant to be restrictive. First, take a good history from your patient. If the patient relates unusual medical problems, take appropriate tests including a complete blood cell count (CBC) and blood chemistry studies using an automated 12-factor analysis system. Next, if the patient has been receiving long-term antibiotic therapy for one year or longer, previous to your first visit, get a 12-factor blood chemistry analysis test and a CBC. Third, if you institute antibiotic therapy, give the patient an information sheet stating in a few words the mild nonserious side effects and the fact that there

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