Transmembrane Signalling via HLA-DR Molecules on T Cells from a Sezary T-Cell Leukaemia Line.

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Abstract
The human Sezary T‐cell leukaemia line. HUT.78, represents a population of activated T cells, i.e. they are HLA‐DR+ and IL‐2R+. We have analysed the capacity of HUT.78cells (1) to stimulate HLA‐DR‐specific T‐cell lines or clones and (2) to be induced to synthesize IL‐2 by anti‐HLA‐DR monoclonal antibodies. The results of our experiments show that HLA‐DR molecules on HUT.78 cells can stimulate at least one HLA‐DR‐specific T‐cell clone and can act as transmembrane signal transmitters.