The effects of fractioned human urine on urease-induced crystallisation in vitro

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Abstract
Previous studies have shown human urine to have an inhibitory action on urease-induced crystallisation. Centrifugation and 0.45 μm filtration of the urine did not reduce this activity. This eliminates larger urine particles as being the cause of the inhibitory activity. Both the retenate and the filtrate after ultrafiltration of urine with a 100.000 mol weight cut-off influenced the urease-induced crystallisation of magnesium ammonium phosphate and calcium phosphate. The results indicate that the inhibitory action is exerted by more than one urinary component.