Recurrent networks in human visual cortex: psychophysical evidence

To study the neuronal circuitry underlying visual spatial-integration processes, we measured the effect of short and long chains of proximal Gabor-signal (GS) flankers $(\sigma =\mathrm{\lambda }=0.15°)$ on the contrast-discrimination function of a foveal GS target. We found that the same pattern of lateral masks enhanced target detection with low-contrast pedestals and strongly suppressed the discrimination of a range of intermediate pedestal contrasts (pedestal contrast <30%). Increasing the number of the flankers reversed the suppressive effect. The data suggest that the main influence of the proximal flankers is maintained by activity-dependent interactions and not by linear spatial summation. With an increased number of flankers, we found a nonmonotonic relationship between the discrimination thresholds and the number of flankers, supporting the notion that the discrimination thresholds are mediated by excitatory–inhibitory recurrent networks that manifest the dynamics of large neuronal populations in the neocortex [Proc. Natl. Acad. Sci. USA 94, 10426 (1997)].