A NEW GENETIC MODEL PROPOSING THAT THE SE GENE IS A STRUCTURAL GENE CLOSELY LINKED TO THE H-GENE

1 January 1981

journal article
research article

Vol. 33 (3) , 421-431

Abstract

The Se gene is considered a regulatory gene controlling the expression of the structural gene H in external secretions. Bombay (h/h) individuals should not be able to express the Se gene. Published Bombay pedigrees (44) suggests no suppression of Se in Bombay individuals, and Se and H loci can be fully expressed at the phenotypic level. Based on a lod score of 12.9 at 1% recombination units and the existence of 2 different acceptors for the biosynthesis of the H antigen, a new genetic model is proposed in which H and Se would be 2 closely linked structural genes coding for 2 different 2-.alpha.-L-fucosyltransferases.

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